Dataset Information
Increased Activation of Default Mode Network in Early Parkinson's With Excessive Daytime Sleepiness.
Ontology highlight
ABSTRACT: Background and objectives
The underlying neuropathology of excessive daytime sleepiness (EDS) remains elusive in Parkinson's disease (PD). We aim to investigate neural network changes that underlie EDS in PD.Methods
Early PD patients comprising eighty-one patients without EDS (EDS-) and seventeen patients with EDS (EDS+) received a resting state functional MRI scan and the Epworth Sleepiness Scale (ESS). Connectivities within the default mode network (DMN), motor and basal ganglia networks were compared between the EDS+ and EDS- groups. Correlations between network connectivity and the severity of EDS were investigated through linear regression.Results
EDS+ patients displayed a trend of increased network connectivity of the posterior DMN (pDMN). A significant positive correlation was found between connectivity of the ventromedial prefrontal cortex in the pDMN and ESS.Conclusion
EDS+ patients are likely to display increased activation in the DMN, suggesting neural compensation in early PD or impaired attentiveness due to mechanisms such as mind-wandering.
SUBMITTER: Ooi LQR
PROVIDER: S-EPMC6920242 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Increased Activation of Default Mode Network in Early Parkinson's With Excessive Daytime Sleepiness.
Frontiers in neuroscience 20191212
<h4>Background and objectives</h4>The underlying neuropathology of excessive daytime sleepiness (EDS) remains elusive in Parkinson's disease (PD). We aim to investigate neural network changes that underlie EDS in PD.<h4>Methods</h4>Early PD patients comprising eighty-one patients without EDS (EDS-) and seventeen patients with EDS (EDS+) received a resting state functional MRI scan and the Epworth Sleepiness Scale (ESS). Connectivities within the default mode network (DMN), motor and basal gangli ...[more]