New Insights into the Lactate Shuttle: Role of MCT4 in the Modulation of the Exercise Capacity.
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ABSTRACT:
SUBMITTER: Bisetto S
PROVIDER: S-EPMC6920289 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
New Insights into the Lactate Shuttle: Role of MCT4 in the Modulation of the Exercise Capacity.
Bisetto Sara S Wright Megan C MC Nowak Romana A RA Lepore Angelo C AC Khurana Tejvir S TS Loro Emanuele E Philp Nancy J NJ
iScience 20191126
Lactate produced by muscle during high-intensity activity is an important end product of glycolysis that supports whole body metabolism. The lactate shuttle model suggested that lactate produced by glycolytic muscle fibers is utilized by oxidative fibers. MCT4 is a proton coupled monocarboxylate transporter preferentially expressed in glycolytic muscle fibers and facilitates the lactate efflux. Here we investigated the exercise capacity of mice with disrupted lactate shuttle due to global deleti ...[more]
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2023-10-01 | GSE242294 | GEO