Efficacy and safety of GLP-1 receptor agonists as add-on to SGLT2 inhibitors in type 2 diabetes mellitus: A meta-analysis.
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ABSTRACT:
SUBMITTER: Castellana M
PROVIDER: S-EPMC6920368 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
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Efficacy and safety of GLP-1 receptor agonists as add-on to SGLT2 inhibitors in type 2 diabetes mellitus: A meta-analysis.
Castellana Marco M Cignarelli Angelo A Brescia Francesco F Perrini Sebastio S Natalicchio Annalisa A Laviola Luigi L Giorgino Francesco F
Scientific reports 20191218 1
GLP-1 receptor agonists (GLP-1RA) and SGLT2 inhibitors (SGLT2i) have been associated with improved glycemic control, body weight loss and favorable changes in cardiovascular risk factors and outcomes. We conducted a systematic review and meta-analysis to evaluate the effects of the addition of GLP-1RA to SGLT2i in patients with type 2 diabetes mellitus and inadequate glycemic control. Six databases were searched until March 2019. Randomized controlled trials (RCT) with a follow-up of at least 24 ...[more]
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