Ontology highlight
ABSTRACT:
SUBMITTER: Ohnishi T
PROVIDER: S-EPMC6920379 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Ohnishi Takashi T Yamada Katsuhisa K Iwasaki Koji K Tsujimoto Takeru T Higashi Hideaki H Kimura Taichi T Iwasaki Norimasa N Sudo Hideki H
Scientific reports 20191218 1
Approximately 40% of people under 30 and over 90% of people 55 or older suffer from moderate-to-severe levels of degenerative intervertebral disc (IVD) disease in their lumbar spines. Surgical treatments are sometimes effective; however, the treatment of back pain related to IVD degeneration is still a challenge; therefore, new treatments are necessary. Apoptosis may be important in IVD degeneration because suppressing cell apoptosis inside the IVD inhibits degeneration. Caspase-3, the primary e ...[more]