Ontology highlight
ABSTRACT:
SUBMITTER: Hasegawa S
PROVIDER: S-EPMC6920429 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Hasegawa Shunsuke S Fukushima Hotaka H Hosoda Hiroshi H Serita Tatsurou T Ishikawa Rie R Rokukawa Tomohiro T Kawahara-Miki Ryouka R Zhang Yue Y Ohta Miho M Okada Shintaro S Tanimizu Toshiyuki T Josselyn Sheena A SA Frankland Paul W PW Kida Satoshi S
Nature communications 20191218 1
Cognitive performance in people varies according to time-of-day, with memory retrieval declining in the late afternoon-early evening. However, functional roles of local brain circadian clocks in memory performance remains unclear. Here, we show that hippocampal clock controlled by the circadian-dependent transcription factor BMAL1 regulates time-of-day retrieval profile. Inducible transgenic dominant negative BMAL1 (dnBMAL1) expression in mouse forebrain or hippocampus disrupted retrieval of hip ...[more]