Ontology highlight
ABSTRACT:
SUBMITTER: Latcheva NK
PROVIDER: S-EPMC6920434 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Latcheva Nina K NK Delaney Taylor L TL Viveiros Jennifer M JM Smith Rachel A RA Bernard Kelsey M KM Harsin Benjamin B Marenda Daniel R DR Liebl Faith L W FLW
Scientific reports 20191218 1
Chromatin remodeling proteins of the chromodomain DNA-binding protein family, CHD7 and CHD8, mediate early neurodevelopmental events including neural migration and differentiation. As such, mutations in either protein can lead to neurodevelopmental disorders. How chromatin remodeling proteins influence the activity of mature synapses, however, is relatively unexplored. A critical feature of mature neurons is well-regulated endocytosis, which is vital for synaptic function to recycle membrane and ...[more]