Unknown

Dataset Information

0

Advances in Lipid and Metal Nanoparticles for Antimicrobial Peptide Delivery.


ABSTRACT: Antimicrobial peptides (AMPs) have been described as excellent candidates to overcome antibiotic resistance. Frequently, AMPs exhibit a wide therapeutic window, with low cytotoxicity and broad-spectrum antimicrobial activity against a variety of pathogens. In addition, some AMPs are also able to modulate the immune response, decreasing potential harmful effects such as sepsis. Despite these benefits, only a few formulations have successfully reached clinics. A common flaw in the druggability of AMPs is their poor pharmacokinetics, common to several peptide drugs, as they may be degraded by a myriad of proteases inside the organism. The combination of AMPs with carrier nanoparticles to improve delivery may enhance their half-life, decreasing the dosage and thus, reducing production costs and eventual toxicity. Here, we present the most recent advances in lipid and metal nanodevices for AMP delivery, with a special focus on metal nanoparticles and liposome formulations.

SUBMITTER: Makowski M 

PROVIDER: S-EPMC6920925 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC9787894 | biostudies-literature
| S-EPMC7406478 | biostudies-literature
| S-EPMC9700905 | biostudies-literature
| S-EPMC10573039 | biostudies-literature
| S-EPMC6401629 | biostudies-literature
| S-EPMC5006671 | biostudies-literature
| S-EPMC8353930 | biostudies-literature
| S-EPMC8955373 | biostudies-literature
| S-EPMC8069739 | biostudies-literature
| S-EPMC3496799 | biostudies-literature