Ontology highlight
ABSTRACT:
SUBMITTER: Edwards MA
PROVIDER: S-EPMC6922060 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Edwards Michael A MA Tattoli Tiffany T Sureja Gagan G Sykes Aaron A Kaniper Scott S Gerhard Glenn S GS
Genetic testing and molecular biomarkers 20191119 12
<b><i>Background:</i></b> Melanocortin 4 receptor (<i>MC4R</i>) is a G-protein-coupled receptor involved in appetite regulation. Mutations in the <i>MC4R</i> gene are the most common cause of monogenic obesity. More than 200 sequence variants in the <i>MC4R</i> gene have been associated with obesity, although the vast majority of these data have been obtained from populations of European ancestry. The prevalence and mutation profile of <i>MC4R</i> is thus poorly characterized in other ancestries ...[more]