Ontology highlight
ABSTRACT:
SUBMITTER: Hertoghs N
PROVIDER: S-EPMC6922402 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Hertoghs Nina N Nijmeijer Bernadien M BM van Teijlingen Nienke H NH Fenton-May Angharad E AE Kaptein Tanja M TM van Hamme John L JL Kappes John C JC Kootstra Neeltje A NA Hahn Beatrice H BH Borrow Persephone P Ribeiro Carla M S CMS Geijtenbeek Teunis B H TBH
PloS one 20191219 12
A single HIV-1 variant establishes infection of the host after sexual contact. Identifying the phenotypic characteristics of these Transmitted Founder (T/F) viruses is important to understand the restriction mechanisms during transmission. Langerhans cells (LCs) are the mucosal dendritic cell subset that has been shown to have a protective role in HIV-1 transmission. Immature LCs efficiently capture and degrade HIV-1 via langerin-mediated restriction. Here we have investigated the capacity of T/ ...[more]