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NR3C2 gene polymorphism is associated with risk of gestational hypertension in Han Chinese women.


ABSTRACT: BACKGROUND:The influence of genetic polymorphisms on the development of gestational hypertension (GH) is unclear. The aim of this study was to examine whether single-nucleotide polymorphisms (SNPs) of the nuclear receptor subfamily 3, group C, member 2 (NR3C2) genes, rs5522, rs2070951, rs5534, s2248038, and s9992256 are associated with GH in Han Chinese women. METHOD:Sanger sequencing was used to analyze the genotypes of rs5522, rs2070951, rs5534, rs2248038, and rs9992256 loci of the NR3C2 gene in 450 patients with GH and 450 healthy controls. RESULTS:The rs5522 dominant model (odds ratio [OR]?=?1.30, 95% confidence interval [CI]: 1.13-1.47, P?

SUBMITTER: Cui Z 

PROVIDER: S-EPMC6922589 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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NR3C2 gene polymorphism is associated with risk of gestational hypertension in Han Chinese women.

Cui Zhenghui Z   Xu Jianyun J   Jiang Wenying W  

Medicine 20191201 50


<h4>Background</h4>The influence of genetic polymorphisms on the development of gestational hypertension (GH) is unclear. The aim of this study was to examine whether single-nucleotide polymorphisms (SNPs) of the nuclear receptor subfamily 3, group C, member 2 (NR3C2) genes, rs5522, rs2070951, rs5534, s2248038, and s9992256 are associated with GH in Han Chinese women.<h4>Method</h4>Sanger sequencing was used to analyze the genotypes of rs5522, rs2070951, rs5534, rs2248038, and rs9992256 loci of  ...[more]

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