Differences in topological progression profile among neurodegenerative diseases from imaging data.
Ontology highlight
ABSTRACT:
SUBMITTER: Garbarino S
PROVIDER: S-EPMC6922631 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
Differences in topological progression profile among neurodegenerative diseases from imaging data.
Garbarino Sara S Lorenzi Marco M Oxtoby Neil P NP Vinke Elisabeth J EJ Marinescu Razvan V RV Eshaghi Arman A Ikram M Arfan MA Niessen Wiro J WJ Ciccarelli Olga O Barkhof Frederik F Schott Jonathan M JM Vernooij Meike W MW Alexander Daniel C DC
eLife 20191213
The spatial distribution of atrophy in neurodegenerative diseases suggests that brain connectivity mediates disease propagation. Different descriptors of the connectivity graph potentially relate to different underlying mechanisms of propagation. Previous approaches for evaluating the influence of connectivity on neurodegeneration consider each descriptor in isolation and match predictions against late-stage atrophy patterns. We introduce the notion of a <i>topological profile</i> - a characteri ...[more]
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