Spill-in counts in the quantification of ¹⁸F-florbetapir on Aβ-negative subjects: the effect of including white matter in the reference region.

ABSTRACT:

Background

We aim to provide a systematic study of the impact of white matter (WM) spill-in on the calculation of standardized uptake value ratios (SUVRs) on Aβ-negative subjects, and we study the effect of including WM in the reference region as a compensation. In addition, different partial volume correction (PVC) methods are applied and evaluated.

Methods

We evaluated magnetic resonance imaging and ¹⁸F-AV-45 positron emission tomography data from 122 cognitively normal (CN) patients recruited at the Alzheimer's Disease Neuroimaging Initiative (ADNI). Cortex SUVRs were obtained by using the cerebellar grey matter (CGM) (SUVR_CGM) and the whole cerebellum (SUVR_WC) as reference regions. The correlations between the different SUVRs and the WM u

SUBMITTER: Lopez-Gonzalez FJ 

PROVIDER: S-EPMC6923310 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature