Unknown

Dataset Information

0

Markers of endothelial pathology to support detection of atrial fibrillation in embolic stroke of undetermined source.


ABSTRACT: A relevant part of embolic strokes of undetermined source (ESUS) is assumed to be cardiogenic. As shown previously, certain biomarkers of endothelial pathology are related to atrial fibrillation (AF). In this long-term follow-up study, we aimed to investigate whether these biomarkers are associated with subsequently diagnosed AF and with atrial cardiopathy. In 98 patients who suffered ischemic stroke of known and unknown origin L-arginine, Asymmetric (ADMA) and Symmetric Dimethylarginine (SDMA) have been measured on follow-up at least one year after index stroke. Stroke-diagnostics were available for all patients, including carotid Intima-Media-Thickness (CIMT) and comprehensive echocardiography studies. CIMT was larger in AF- compared with ESUS-patients (P?2DS2VASC in the regression analysis (P?=?0.004). SDMA-values were stable over time (P?2DS2VASC and renal function in the regression analysis (P?=?0.02 and P?=?0.005, respectively). In conclusion, these results highlight SDMA and CIMT as potential markers of atrial cardiopathy and AF in ESUS-patients.

SUBMITTER: Ziegler NL 

PROVIDER: S-EPMC6923420 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Markers of endothelial pathology to support detection of atrial fibrillation in embolic stroke of undetermined source.

Ziegler Nora L NL   Sieweke Jan-Thorben JT   Biber Saskia S   Gabriel Maria M MM   Schuppner Ramona R   Worthmann Hans H   Martens-Lobenhoffer Jens J   Lichtinghagen Ralf R   Bode-Böger Stefanie M SM   Bavendiek Udo U   Weissenborn Karin K   Grosse Gerrit M GM  

Scientific reports 20191219 1


A relevant part of embolic strokes of undetermined source (ESUS) is assumed to be cardiogenic. As shown previously, certain biomarkers of endothelial pathology are related to atrial fibrillation (AF). In this long-term follow-up study, we aimed to investigate whether these biomarkers are associated with subsequently diagnosed AF and with atrial cardiopathy. In 98 patients who suffered ischemic stroke of known and unknown origin L-arginine, Asymmetric (ADMA) and Symmetric Dimethylarginine (SDMA)  ...[more]

Similar Datasets

| S-EPMC8015049 | biostudies-literature
| S-EPMC6490022 | biostudies-literature
| S-EPMC10978394 | biostudies-literature
| S-EPMC10944994 | biostudies-literature
| S-EPMC7902455 | biostudies-literature
| S-EPMC8215436 | biostudies-literature
| S-EPMC6533811 | biostudies-literature
| S-EPMC8258144 | biostudies-literature
| S-EPMC7042078 | biostudies-literature
| S-EPMC11366165 | biostudies-literature