Identification of a novel cholesterol-lowering dipeptide, phenylalanine-proline (FP), and its down-regulation of intestinal ABCA1 in hypercholesterolemic rats and Caco-2 cells.
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ABSTRACT:
SUBMITTER: Banno A
PROVIDER: S-EPMC6923426 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
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Identification of a novel cholesterol-lowering dipeptide, phenylalanine-proline (FP), and its down-regulation of intestinal ABCA1 in hypercholesterolemic rats and Caco-2 cells.
Banno Arata A Wang Jilite J Okada Kenji K Mori Ryosuke R Mijiti Maihemuti M Nagaoka Satoshi S
Scientific reports 20191219 1
There has been no report about in vivo active cholesterol-lowering dipeptide in any protein origin, despite their potential health benefits. Cattle heart protein hydrolysate ultra-filtrate (HPHU, molecular weight < ca. 1,000 Da peptide mixture) exhibits cholesterol-lowering activity in hypercholesterolemic rats, but the active peptide in HPHU that lowers serum cholesterol levels and its molecular mechanism are unknown. In this study, we separated and purified HPHU to identify a novel cholesterol ...[more]
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