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Circulating acetoacetate is associated with poor prognosis in heart failure patients.


ABSTRACT: Background:Acetoacetate is used as an alternative energy source in the heart, and has the potential to improve cardiac function. However, the prognostic impact of acetoacetate has not been investigated in heart failure. Methods:This study enrolled consecutive 615 hospitalized patients with heart failure. We investigated the associations between circulating acetoacetate and clinical characteristics or prognosis in HF patients. Results:We divided the patients into two groups based on circulating acetoacetate levels (high group: acetoacetate ?35?µmoL/L, n?=?313; and low group: acetoacetate <35?µmoL/L, n?=?302). The high group had an older age (68 vs. 65?years, P?=?0.003) and higher log brain natriuretic peptide levels (2.43 vs. 2.23, P?

SUBMITTER: Yokokawa T 

PROVIDER: S-EPMC6923508 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Circulating acetoacetate is associated with poor prognosis in heart failure patients.

Yokokawa Tetsuro T   Yoshihisa Akiomi A   Kanno Yuki Y   Abe Satoshi S   Misaka Tomofumi T   Yamada Shinya S   Kaneshiro Takashi T   Sato Takamasa T   Oikawa Masayoshi M   Kobayashi Atsushi A   Nakazato Kazuhiko K   Ishida Takafumi T   Takeishi Yasuchika Y  

International journal of cardiology. Heart & vasculature 20191107


<h4>Background</h4>Acetoacetate is used as an alternative energy source in the heart, and has the potential to improve cardiac function. However, the prognostic impact of acetoacetate has not been investigated in heart failure.<h4>Methods</h4>This study enrolled consecutive 615 hospitalized patients with heart failure. We investigated the associations between circulating acetoacetate and clinical characteristics or prognosis in HF patients.<h4>Results</h4>We divided the patients into two groups  ...[more]

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