Proinsulin associates with poor ?-cell function, glucose-dependent insulinotropic peptide, and insulin resistance in persistent type 2 diabetes after Roux-en-Y gastric bypass in humans.

ABSTRACT: BACKGROUND:The determinants of type 2 diabetes (T2D) remission and/or relapse after gastric bypass (RYGB) remain fully unknown. This study characterized ?- and ?-cell function, in cretin hormone release and insulin sensitivity in individuals with (remitters) or without (non-remitters) diabetes remission after RYGB. METHODS:This is a cross-sectional study of two distinct cohorts of individuals with or without diabetes remission at least 2?years after RYGB. Each individual underwent-either an oral glucose (remitters) or a mixed meal (non-remitters) test; glucose, proinsulin, insulin, C-peptide, glucagon, incretins and leptin were measured. RESULTS:Compared to remitters (n = 23), non-remitters (n = 31) were older (mean [±SD] age 56.1?±?8.2 vs. 46.0?±?8.9?years, P?

SUBMITTER: Patel K 

PROVIDER: S-EPMC6923566 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature