Electrostatic Complementarity Drives Amyloid/Nucleic Acid Co-Assembly.
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ABSTRACT:
SUBMITTER: Rha AK
PROVIDER: S-EPMC6923580 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
Electrostatic Complementarity Drives Amyloid/Nucleic Acid Co-Assembly.
Rha Allisandra K AK Das Dibyendu D Taran Olga O Ke Yonggang Y Mehta Anil K AK Lynn David G DG
Angewandte Chemie (International ed. in English) 20191114 1
Proteinaceous plaques associated with neurodegenerative diseases contain many biopolymers including the polyanions glycosaminoglycans and nucleic acids. Polyanion-induced amyloid fibrillation has been implicated in disease etiology, but structural models for amyloid/nucleic acid co-assemblies remain limited. Here we constrain nucleic acid/peptide interactions with model peptides that exploit electrostatic complementarity and define a novel amyloid/nucleic acid co-assembly. The structure provides ...[more]
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