Ontology highlight
ABSTRACT:
SUBMITTER: Zhang S
PROVIDER: S-EPMC6923703 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Zhang Shugang S Zhang Shanzhuo S Fan Xiaoshuai X Wang Wei W Li Zhen Z Jia Dongning D Wei Zhiqiang Z Zhang Henggui H
Frontiers in physiology 20191213
Hydrogen sulfide (H<sub>2</sub>S), an ambient air pollutant, has been reported to increase cardiac events in patients with cardiovascular diseases, but the underlying mechanisms remain not elucidated. This study investigated the pro-arrhythmic effects of H<sub>2</sub>S in healthy and ischemic conditions. Experimental data of H<sub>2</sub>S effects on ionic channels (including the L-type Ca<sup>2+</sup> channel and ATP-sensitive K<sup>+</sup> channel) were incorporated into a virtual heart model ...[more]