Ontology highlight
ABSTRACT:
SUBMITTER: Yu N
PROVIDER: S-EPMC6923973 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Yu Na N Chen Pei P Wang Qiyun Q Liang Meixin M Qiu Jin J Zhou Pan P Yang Meng M Yang Panyang P Wu Yihui Y Han Xiaokun X Ge Jian J Zhuang Jing J Yu Keming K
Oncology letters 20191119 1
Retinoblastoma (RB) is the most prevalent childhood intraocular cancer type. Previous studies have demonstrated that <i>c-myc</i> (a proto-oncogene) is associated with tumorigenesis. However, at present, the influence of the expression profile and bioactivity of c-Myc on RB occurrence and progression is yet to be characterised. Notably, the present study demonstrated that <i>c-myc</i> is downregulated in the RB cell line WERI-Rb1. However, treatment with the histone deacetylase (HDAC) inhibitor ...[more]