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ABSTRACT: Background
Most patients with cystic fibrosis (CF) suffer from pancreatic insufficiency, leading to fat malabsorption, malnutrition and abdominal discomfort. Until recently, no specific tool was available for assessing gastro-intestinal related quality of life (GI QOL) in patients with CF. As the Horizon2020 project MyCyFAPP aims to improve GI QOL by using a newly designed mobile application, a sensitive and reliable outcome measure was needed. We aimed to study the applicability of the existing child-specific Pediatric Quality of Life Inventory, Gastrointestinal Symptoms Scales and Module (PedsQL GI) in children with CF.Methods
A multicenter, prospective observational study was performed in 6 European centers to validate the PedsQL GI in children with CF during 3 months.Results
In total, 248 children and their parents were included. Within-patient variability of PedsQL GI was low (24.11), and there was reasonable agreement between children and parents (ICC 0.681). Nine of 14 subscales were informative (no ceiling effect). The PedsQL GI and the median scores for 4 subscales were significantly lower in patients compared to healthy controls. Positive associations were found between PedsQL GI and age (OR = 1.044, p = 0.004) and between PedsQL GI and BMI z-score (OR = 1.127, p = 0.036). PedsQL GI correlated with most CFQ-R subscales (r 0.268 to 0.623) and with a Visual Analogue Scale (r = 0.20).Conclusions
PedsQL GI is a valid and applicable instrument to assess GI QOL in children with CF. Future research efforts should examine the responsiveness of the CF PedsQL GI to change in the context of clinical interventions and trials.
SUBMITTER: Boon M
PROVIDER: S-EPMC6924691 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Boon Mieke M Claes Ine I Havermans Trudy T Fornés-Ferrer Victoria V Calvo-Lerma Joaquim J Asseiceira Inês I Bulfamante Anna A Garriga María M Masip Etna E Woodcock Sandra S Walet Sylvia S Barreto Celeste C Colombo Carla C Crespo Paula P Van der Wiel Els E Hulst Jessie J Martinez-Barona Sandra S Nobili Rita R Pereira Luisa L Ruperto Mar M Vicente Saioa S De Boeck Kris K Ribes-Koninckx Carmen C
PloS one 20191220 12
<h4>Background</h4>Most patients with cystic fibrosis (CF) suffer from pancreatic insufficiency, leading to fat malabsorption, malnutrition and abdominal discomfort. Until recently, no specific tool was available for assessing gastro-intestinal related quality of life (GI QOL) in patients with CF. As the Horizon2020 project MyCyFAPP aims to improve GI QOL by using a newly designed mobile application, a sensitive and reliable outcome measure was needed. We aimed to study the applicability of the ...[more]