Ontology highlight
ABSTRACT:
SUBMITTER: Rudler DL
PROVIDER: S-EPMC6924987 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Rudler Danielle L DL Hughes Laetitia A LA Perks Kara L KL Richman Tara R TR Kuznetsova Irina I Ermer Judith A JA Abudulai Laila N LN Shearwood Anne-Marie J AJ Viola Helena M HM Hool Livia C LC Siira Stefan J SJ Rackham Oliver O Filipovska Aleksandra A
Science advances 20191220 12
Mammalian mitochondrial ribosomes are unique molecular machines that translate 11 leaderless mRNAs; however, it is not clear how mitoribosomes initiate translation, since mitochondrial mRNAs lack untranslated regions. Mitochondrial translation initiation shares similarities with prokaryotes, such as the formation of a ternary complex of fMet-tRNA<sup>Met</sup>, mRNA and the 28<i>S</i> subunit, but differs in the requirements for initiation factors. Mitochondria have two initiation factors: MTIF2 ...[more]