Ontology highlight
ABSTRACT:
SUBMITTER: Pang K
PROVIDER: S-EPMC6925134 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Pang Kyoungwha K Park Jinah J Ahn Sung Gwe SG Lee Jihee J Park Yuna Y Ooshima Akira A Mizuno Seiya S Yamashita Satoshi S Park Kyung-Soon KS Lee So-Young SY Jeong Joon J Ushijima Toshikazu T Yang Kyung-Min KM Kim Seong-Jin SJ
Nature communications 20191220 1
The development of triple-negative breast cancer (TNBC) negatively impacts both quality of life and survival in a high percentage of patients. Here, we show that RING finger protein 208 (RNF208) decreases the stability of soluble Vimentin protein through a polyubiquitin-mediated proteasomal degradation pathway, thereby suppressing metastasis of TNBC cells. RNF208 was significantly lower in TNBC than the luminal type, and low expression of RNF208 was strongly associated with poor clinical outcome ...[more]