Ontology highlight
ABSTRACT:
SUBMITTER: Black MJ
PROVIDER: S-EPMC6925616 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Nature chemistry 20191202 1
Flavin-dependent 'ene'-reductases (EREDs) are exquisite catalysts for effecting stereoselective reductions. Although these reactions typically proceed through a hydride transfer mechanism, we recently found that EREDs can also catalyse reductive dehalogenations and cyclizations via single electron transfer mechanisms. Here, we demonstrate that these enzymes can catalyse redox-neutral radical cyclizations to produce enantioenriched oxindoles from α-haloamides. This transformation is a C-C bond-fo ...[more]