Fine Particulate Matter Leads to Unfolded Protein Response and Shortened Lifespan by Inducing Oxidative Stress in C. elegans.
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ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC6925806 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
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Fine Particulate Matter Leads to Unfolded Protein Response and Shortened Lifespan by Inducing Oxidative Stress in <i>C. elegans</i>.
Zhao Yunli Y Jin Ling L Chi Yuxin Y Yang Jing J Zhen Quan Q Wu Huazhang H
Oxidative medicine and cellular longevity 20191207
Oxidative stress has been proven as one of the most critical regulatory mechanisms involved in fine Particulate Matter- (PM<sub>2.5</sub>-) mediated toxicity. For a better understanding of the underlying mechanisms that enable oxidative stress to participate in PM<sub>2.5</sub>-induced toxic effects, the current study explored the effects of oxidative stress induced by PM<sub>2.5</sub> on UPR and lifespan in <i>C. elegans</i>. The results implicated that PM<sub>2.5</sub> exposure induced oxidati ...[more]
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