Ontology highlight
ABSTRACT:
SUBMITTER: Augenstreich J
PROVIDER: S-EPMC6926010 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Augenstreich Jacques J Haanappel Evert E Ferré Guillaume G Czaplicki Georges G Jolibois Franck F Destainville Nicolas N Guilhot Christophe C Milon Alain A Astarie-Dequeker Catherine C Chavent Matthieu M
Proceedings of the National Academy of Sciences of the United States of America 20191122 51
Phthiocerol dimycocerosate (DIM) is a major virulence factor of the pathogen <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>). While this lipid promotes the entry of <i>Mtb</i> into macrophages, which occurs via phagocytosis, its molecular mechanism of action is unknown. Here, we combined biophysical, cell biology, and modeling approaches to reveal the molecular mechanism of DIM action on macrophage membranes leading to the first step of <i>Mtb</i> infection. Matrix-assisted laser desorption ioniz ...[more]