Ontology highlight
ABSTRACT:
SUBMITTER: Vuckovic Z
PROVIDER: S-EPMC6926013 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Vuckovic Ziva Z Gentry Patrick R PR Berizzi Alice E AE Hirata Kunio K Varghese Swapna S Thompson Geoff G van der Westhuizen Emma T ET Burger Wessel A C WAC Rahmani Raphaël R Valant Celine C Langmead Christopher J CJ Lindsley Craig W CW Baell Jonathan B JB Tobin Andrew B AB Sexton Patrick M PM Christopoulos Arthur A Thal David M DM
Proceedings of the National Academy of Sciences of the United States of America 20191126 51
The human M<sub>5</sub> muscarinic acetylcholine receptor (mAChR) has recently emerged as an exciting therapeutic target for treating a range of disorders, including drug addiction. However, a lack of structural information for this receptor subtype has limited further drug development and validation. Here we report a high-resolution crystal structure of the human M<sub>5</sub> mAChR bound to the clinically used inverse agonist, tiotropium. This structure allowed for a comparison across all 5 mA ...[more]