Ontology highlight
ABSTRACT:
SUBMITTER: Chernov-Rogan T
PROVIDER: S-EPMC6926016 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Chernov-Rogan Tania T Gianti Eleonora E Liu Chang C Villemure Elisia E Cridland Andrew P AP Hu Xiaoyu X Ballini Elisa E Lange Wienke W Deisemann Heike H Li Tianbo T Ward Stuart I SI Hackos David H DH Magnuson Steven S Safina Brian B Klein Michael L ML Volgraf Matthew M Carnevale Vincenzo V Chen Jun J
Proceedings of the National Academy of Sciences of the United States of America 20191203 51
The transient receptor potential ankyrin 1 (TRPA1) channel functions as an irritant sensor and is a therapeutic target for treating pain, itch, and respiratory diseases. As a ligand-gated channel, TRPA1 can be activated by electrophilic compounds such as allyl isothiocyanate (AITC) through covalent modification or activated by noncovalent agonists through ligand binding. However, how covalent modification leads to channel opening and, importantly, how noncovalent binding activates TRPA1 are not ...[more]