Production of tetra-methylpyrazine using engineered Corynebacterium glutamicum.
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ABSTRACT:
SUBMITTER: Eng T
PROVIDER: S-EPMC6926172 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
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Production of tetra-methylpyrazine using engineered <i>Corynebacterium glutamicum</i>.
Eng Thomas T Sasaki Yusuke Y Herbert Robin A RA Lau Andrew A Trinh Jessica J Chen Yan Y Mirsiaghi Mona M Petzold Christopher J CJ Mukhopadhyay Aindrila A
Metabolic engineering communications 20191202
<i>Corynebacterium glutamicum</i> ATCC 13032 is an established and industrially-relevant microbial host that has been utilized for the expression of many desirable bioproducts. Tetra-methylpyrazine (TMP) is a naturally occurring alkylpyrazine with broad applications spanning fragrances to resins. We identified an engineered strain of <i>C. glutamicum</i> which produces 5 g/L TMP and separately, a strain which can co-produce both TMP and the biofuel compound isopentenol. Ionic liquids also stimu ...[more]
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