Ontology highlight
ABSTRACT:
SUBMITTER: Deskin B
PROVIDER: S-EPMC6926313 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Deskin Brian B Yin Qinyan Q Zhuang Yan Y Saito Shigeki S Shan Bin B Lasky Joseph A JA
Translational oncology 20191219 2
Histone deacetylase 6 (HDAC6) regulates cytoplasmic signaling networks through deacetylation of various cytoplasmic substrates and serves as a key member of the ubiquitin proteasome system (UPS). This study is focused on HDAC6 regulation of the Notch1 receptor that plays a crucial role in tumor growth in NSCLC. A series of cell culture experiments were employed using A549, Lewis lung carcinoma 2 (LL2), and H1299 NSCLC cell lines to investigate HDAC6-mediated regulation of the Notch1 receptor thr ...[more]