Ontology highlight
ABSTRACT:
SUBMITTER: Ratnakumar A
PROVIDER: S-EPMC6926344 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Ratnakumar Abhirami A Zimmerman Samuel E SE Jordan Bryen A BA Mar Jessica C JC
Alzheimer's & dementia (New York, N. Y.) 20191209
<h4>Introduction</h4>Women are at increased risk for Alzheimer's disease (AD), but the reason why remains unknown. One hypothesis is that low estrogen levels at menopause increases vulnerability to AD, but this remains unproven.<h4>Methods</h4>We compared neuronal genes upregulated by estrogen in ovariectomized female rhesus macaques with a database of >17,000 diverse gene sets and applied a rare variant burden test to exome sequencing data from 1208 female AD patients with the age of onset < 75 ...[more]