Telomere length associations with cognition depend on Alzheimer's disease biomarkers.
Ontology highlight
ABSTRACT:
SUBMITTER: Mahoney ER
PROVIDER: S-EPMC6926345 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Telomere length associations with cognition depend on Alzheimer's disease biomarkers.
Mahoney Emily R ER Dumitrescu Logan L Seto Mabel M Nudelman Kelly N H KNH Buckley Rachel F RF Gifford Katie A KA Saykin Andrew J AJ Jefferson Angela J AJ Hohman Timothy J TJ
Alzheimer's & dementia (New York, N. Y.) 20191209
<h4>Introduction</h4>While telomere shortening, a marker of cellular aging, may impact the progression of age-related neurodegenerative diseases, its association with cognition is unclear, particularly in the context of Alzheimer's disease (AD) pathology.<h4>Methods</h4>Telomere, cognitive, and CSF data from 482 participants in the AD Neuroimaging Initiative (148 cognitively normal, 283 mild cognitive impairment, 51 AD) was leveraged to assess telomere length associations with cognition (measure ...[more]
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