Ontology highlight
ABSTRACT:
SUBMITTER: Adhikari A
PROVIDER: S-EPMC6926451 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Adhikari Abhinav A Mainali Pramish P Davie Judith K JK
The Journal of biological chemistry 20191002 51
JARID2 is a noncatalytic member of the polycomb repressive complex 2 (PRC2) which methylates of histone 3 lysine 27 (H3K27). In this work, we show that JARID2 and the PRC2 complex regulate the cell cycle in skeletal muscle cells to control proliferation and mitotic exit. We found that the stable depletion of JARID2 leads to increased proliferation and cell accumulation in S phase. The regulation of the cell cycle by JARID2 is mediated by direct repression of both cyclin D1 and cyclin E1, both of ...[more]