Ontology highlight
ABSTRACT:
SUBMITTER: Masui K
PROVIDER: S-EPMC6926466 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Masui Kenta K Harachi Mio M Ikegami Shiro S Yang Huijun H Onizuka Hiromi H Yong William H WH Cloughesy Timothy F TF Muragaki Yoshihiro Y Kawamata Takakazu T Arai Nobutaka N Komori Takashi T Cavenee Webster K WK Mischel Paul S PS Shibata Noriyuki N
The Journal of biological chemistry 20191111 51
In cancer, aberrant growth factor receptor signaling reprograms cellular metabolism and global gene transcription to drive aggressive growth, but the underlying mechanisms are not well-understood. Here we show that in the highly lethal brain tumor glioblastoma (GBM), mTOR complex 2 (mTORC2), a critical core component of the growth factor signaling system, couples acetyl-CoA production with nuclear translocation of histone-modifying enzymes including pyruvate dehydrogenase and class IIa histone d ...[more]