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A Facile Synthesis of Core-Shell SiO2@Cu-LBMS Nano-Microspheres for Drug Sustained Release Systems.


ABSTRACT: A well-dispersed SiO2@Layered hydroxide cupric benzoate (SiO2@Cu-LBMS) with a hierarchical structure have been synthesized by a facile method. The layered hydroxide cupric benzoate with a structure of layered basic metal salt (Cu-LBMS) was directly deposited on the surface of silica spheres without any blinder. The morphology of the SiO2@Cu-LBMS nano-microsphere was observed by SEM, and the reaction conditions was also discussed. In addition, the XRD patterns and FTIR spectra provide consistent evidence to the formation of SiO2@Cu-LBMS nano-microspheres. The release behavior and drug loading capability of SiO2@Cu-LBMS microspheres were also investigated by using ibuprofen, aspirin and salicylic acid as model drugs. The results indicated that the drug loading capability of SiO2@Cu-LBMS nano-microspheres was much larger than layered hydroxide cupric benzoate, and the releasing time was significantly prolonged than layered hydroxide cupric benzoate and their physical mixture.

SUBMITTER: Wang H 

PROVIDER: S-EPMC6926544 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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A Facile Synthesis of Core-Shell SiO<sub>2</sub>@Cu-LBMS Nano-Microspheres for Drug Sustained Release Systems.

Wang Hui H   Yang Haifeng H   Zhao Lifang L  

Materials (Basel, Switzerland) 20191130 23


A well-dispersed SiO<sub>2</sub>@Layered hydroxide cupric benzoate (SiO<sub>2</sub>@Cu-LBMS) with a hierarchical structure have been synthesized by a facile method. The layered hydroxide cupric benzoate with a structure of layered basic metal salt (Cu-LBMS) was directly deposited on the surface of silica spheres without any blinder. The morphology of the SiO<sub>2</sub>@Cu-LBMS nano-microsphere was observed by SEM, and the reaction conditions was also discussed. In addition, the XRD patterns and  ...[more]

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