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Substitutions of Zr⁴⁺/V⁵⁺ for Y³⁺/Mo⁶⁺ in Y₂Mo₃O₁₂ for Less Hygroscopicity and Low Thermal Expansion Properties.

ABSTRACT: In this investigation, Zr_xY_2-xV_xMo_3-xO₁₂ (0 ≤ x ≤ 1.4) is developed and the effects of the substitutions of Zr⁴⁺/V⁵⁺ for Y³⁺/Mo⁶⁺ in Y₂Mo₃O₁₂ on the hygroscopicity and thermal expansion property are investigated. For the smaller substitution content (x ≤ 0.5), their crystal structures remain orthorhombic, while there is crystal water still in the lattice. The linear coefficients of thermal expansions (CTEs), for x = 0.1, 0.3, 0.5, and 0.7, are about -4.30 × 10^-6, -0.97 × 10^-6, 0.85 × 10^-6, and 0.77 × 10^-6 K^-1, respectively, from 476 to 773 K, which means that the linear CTE could be changed linearly with the substitution content of Zr⁴⁺/V⁵⁺ for Y³⁺/Mo⁶⁺ in Y₂Mo₃O₁₂. As long as the substitution content reaches x = 1.3/1.4, almost no hygroscopicity and low thermal expansion from room temperature are obtained and are discussed in relation to the crystal structure and microstructure.

SUBMITTER: Ma Q

PROVIDER: S-EPMC6926913 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:BackgroundIn vivo monitoring of cell biodistribution using positron emission tomography (PET) provides a quantitative non-invasive method to further optimize cell therapies and related new developments in the field. Our group has earlier optimized and evaluated the in vitro properties of two radiotracers,[89Zr]Zr-(oxinate)4 and [89Zr]Zr-DFO-NCS, for the radiolabelling of different cell types. Here, we performed a microPET study to assess the in vivo biodistribution of cells in rats using these two radiotracers. Human decidual stromal cells (hDSC) and rat macrophages (rMac) were radiolabelled with [89Zr]Zr-(oxinate)4 or [89Zr]Zr-DFO-NCS. Rats were intravenously injected with radiolabelled cells, and the in vivo biodistribution was monitored with microPET/CT imaging for up to day 7. Organ uptake was evaluated and presented as a percentage of injected activity per gram tissue (%IA/g) and total absorbed organ doses (mSv/MBq).ResultsThe biodistribution in vivo showed an immediate uptake in the lungs. Thereafter, [89Zr]Zr-(oxinate)4 labelled cells migrated to the liver, while the signal from [89Zr]Zr-DFO-NCS labelled cells lingered in the lungs. The differences in the in vivo behaviour for the same cell type appeared related to the radiotracer labelling. After 24 h, [89Zr]Zr-(oxinate)4 labelled cells had over 70% higher liver uptake for both hDSC and rMac compared to [89Zr]Zr-DFO-NCS labelled cells, whereas [89Zr]Zr-DFO-NCS labelled cells showed over 60% higher uptake in the lungs compared to [89Zr]Zr-(oxinate)4 labelled cells. This difference in both lung and liver uptake continued until day 7. Dosimetry calculations showed a higher effective dose (mSv/MBq) for [89Zr]Zr-DFO-NCS compared to [89Zr]Zr-(oxinate)4, for both cell types. Although the bone uptake was higher for [89Zr]Zr-(oxinate)4 labelled cells, the prolonged uptake in the lungs contributed to a significant crossfire to bone marrow resulting in a higher bone dose.ConclusionThe [89Zr]Zr-DFO-NCS labelled cells suggest a prolonged accumulation in the lungs, while [89Zr]Zr-(oxinate)4 suggests quicker clearance of the lungs followed by accumulation in the liver. Accumulation of radiolabelled cells in the liver corresponds to other cell-tracking methods. Further studies are required to determine the actual location of the [89Zr]Zr-DFO-NCS labelled cell.

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Substitutions of Zr⁴⁺/V⁵⁺ for Y³⁺/Mo⁶⁺ in Y₂Mo₃O₁₂ for Less Hygroscopicity and Low Thermal Expansion Properties.

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Substitutions of Zr4+/V5+ for Y3+/Mo6+ in Y2Mo3O12 for Less Hygroscopicity and Low Thermal Expansion Properties.

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OmicsDI is part of the ELIXIR infrastructure

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Substitutions of Zr⁴⁺/V⁵⁺ for Y³⁺/Mo⁶⁺ in Y₂Mo₃O₁₂ for Less Hygroscopicity and Low Thermal Expansion Properties.