Ontology highlight
ABSTRACT:
SUBMITTER: Stintzing S
PROVIDER: S-EPMC6927316 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Stintzing S S Wirapati P P Lenz H-J HJ Neureiter D D Fischer von Weikersthal L L Decker T T Kiani A A Kaiser F F Al-Batran S S Heintges T T Lerchenmüller C C Kahl C C Seipelt G G Kullmann F F Moehler M M Scheithauer W W Held S S Modest D P DP Jung A A Kirchner T T Aderka D D Tejpar S S Heinemann V V
Annals of oncology : official journal of the European Society for Medical Oncology 20191101 11
<h4>Background</h4>FIRE-3 compared first-line therapy with FOLFIRI plus either cetuximab or bevacizumab in 592 KRAS exon 2 wild-type metastatic colorectal cancer (mCRC) patients. The consensus molecular subgroups (CMS) are grouping CRC samples according to their gene-signature in four different subtypes. Relevance of CMS for the treatment of mCRC has yet to be defined.<h4>Patients and methods</h4>In this exploratory analysis, patients were grouped according to the previously published tumor CRC- ...[more]