Ontology highlight
ABSTRACT:
SUBMITTER: Luck R
PROVIDER: S-EPMC6927742 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Luck Robert R Urban Severino S Karakatsani Andromachi A Harde Eva E Sambandan Sivakumar S Nicholson LaShae L Haverkamp Silke S Mann Rebecca R Martin-Villalba Ana A Schuman Erin Margaret EM Acker-Palmer Amparo A Ruiz de Almodóvar Carmen C
eLife 20191223
Axon branching is crucial for proper formation of neuronal networks. Although originally identified as an angiogenic factor, VEGF also signals directly to neurons to regulate their development and function. Here we show that VEGF and its receptor VEGFR2 (also known as KDR or FLK1) are expressed in mouse hippocampal neurons during development, with VEGFR2 locally expressed in the CA3 region. Activation of VEGF/VEGFR2 signaling in isolated hippocampal neurons results in increased axon branching. R ...[more]