Ontology highlight
ABSTRACT:
SUBMITTER: Palomo-Guerrero M
PROVIDER: S-EPMC6927751 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Palomo-Guerrero Marta M Fadó Rut R Casas Maria M Pérez-Montero Marta M Baena Miguel M Helmer Patrick O PO Domínguez José Luis JL Roig Aina A Serra Dolors D Hayen Heiko H Stenmark Harald H Raiborg Camilla C Casals Núria N
eLife 20191223
Anterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored. Malonyl-CoA is a precursor of fatty acids, and its intracellular levels highly fluctuate depending on glucose availability or the energy sensor AMP-activated protein kinase (AMPK). We demonstrate in HeLa cells that carnitine palmitoyltransferase 1C (CPT1C) senses malonyl-CoA and enhances LE/Lys anterograde transport by interacting wit ...[more]