Ontology highlight
ABSTRACT:
SUBMITTER: Castaneyra-Ruiz L
PROVIDER: S-EPMC6927874 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Castaneyra-Ruiz Leandro L Morales Diego M DM McAllister James P JP Brody Steven L SL Isaacs Albert M AM Strahle Jennifer M JM Dahiya Sonika M SM Limbrick David D DD
Journal of neuropathology and experimental neurology 20180901 9
Intraventricular hemorrhage (IVH) is the most common cause of pediatric hydrocephalus in North America but remains poorly understood. Cell junction-mediated ventricular zone (VZ) disruption and astrogliosis are associated with the pathogenesis of congenital, nonhemorrhagic hydrocephalus. Recently, our group demonstrated that VZ disruption is also present in preterm infants with IVH. On the basis of this observation, we hypothesized that blood triggers the loss of VZ cell junction integrity and r ...[more]