Ontology highlight
ABSTRACT:
SUBMITTER: Janjic K
PROVIDER: S-EPMC6927906 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Janjić Klara K Samiei Mohammad M Moritz Andreas A Agis Hermann H
Frontiers in bioengineering and biotechnology 20191217
Sclerostin (Sost) and dickkopf (Dkk)-1 are inhibitors of the Wnt signaling pathway that plays a role in regenerative processes. Hypoxia-based strategies are used for regenerative approaches, but the influence of hypoxia on Sost and Dkk-1 production in a pro-inflammatory environment is unclear. The aim of this study was to assess if pro-inflammatory molecules have an influence on Sost and Dkk-1 production in dental pulp cells (DPC) under normoxia and hypoxia. Human DPC were treated with interleuk ...[more]