Ontology highlight
ABSTRACT:
SUBMITTER: Diaz-Valle A
PROVIDER: S-EPMC6928768 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Díaz-Valle Armando A Falcón-González José Marcos JM Carrillo-Tripp Mauricio M
International journal of molecular sciences 20191127 23
The viral capsid is a macromolecular complex formed by a defined number of self-assembled proteins, which, in many cases, are biopolymers with an identical amino acid sequence. Specific protein-protein interactions (PPI) drive the capsid self-assembly process, leading to several distinct protein interfaces. Following the PPI hot spot hypothesis, we present a conservation-based methodology to identify those interface residues hypothesized to be crucial elements on the self-assembly and thermodyna ...[more]