Unknown

Dataset Information

0

Incorporation of drug efflux inhibitor and chemotherapeutic agent into an inorganic/organic platform for the effective treatment of multidrug resistant breast cancer.


ABSTRACT:

Background

Multidrug resistance (MDR) is a pressing obstacle in clinical chemotherapy for breast cancer. Based on the fact that the drug efflux is an important factor in MDR, we designed a codelivery system to guide the drug efflux inhibitor verapamil (VRP) and the chemotherapeutic agent novantrone (NVT) synergistically into breast cancer cells to reverse MDR.

Results

This co-delivery system consists of following components: the active targeting peptide RGD, an inorganic calcium phosphate (CaP) shell and an organic inner core. VRP and NVT were loaded into CaP shell and phosphatidylserine polyethylene glycol (PS-PEG) core of nanoparticles (NPs) separately to obtain NVT- and VRP-loaded NPs (NV@CaP-RGD). These codelivered NPs allowed VRP to prevent the efflux of NVT from breast cancer cells by competitively combining with drug efflux pumps. Additionally, NV@CaP-RGD was effectively internalized into breast cancer cells by precise delivery through the effects of the active targeting peptides RGD and EPR. The pH-triggered profile of CaP was also able to assist the NPs to successfully escape from lysosomes, leading to a greatly increased effective intracellular drug concentration.

Conclusion

The concurrent administration of VRP and NVT by organic/inorganic NPs is a promising therapeutic approach to reverse MDR in breast cancer.

SUBMITTER: Dong Y 

PROVIDER: S-EPMC6929438 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Incorporation of drug efflux inhibitor and chemotherapeutic agent into an inorganic/organic platform for the effective treatment of multidrug resistant breast cancer.

Dong Yang Y   Liao Hongze H   Yu Jian J   Fu Hao H   Zhao De   Gong Ke K   Wang Qi Q   Duan Yourong Y  

Journal of nanobiotechnology 20191223 1


<h4>Background</h4>Multidrug resistance (MDR) is a pressing obstacle in clinical chemotherapy for breast cancer. Based on the fact that the drug efflux is an important factor in MDR, we designed a codelivery system to guide the drug efflux inhibitor verapamil (VRP) and the chemotherapeutic agent novantrone (NVT) synergistically into breast cancer cells to reverse MDR.<h4>Results</h4>This co-delivery system consists of following components: the active targeting peptide RGD, an inorganic calcium p  ...[more]

Similar Datasets

| S-EPMC3166226 | biostudies-other
| S-EPMC3983711 | biostudies-literature
| S-EPMC8097430 | biostudies-literature
| S-EPMC4335044 | biostudies-literature
| S-EPMC7017071 | biostudies-literature
| S-EPMC7402219 | biostudies-literature
| S-EPMC6045373 | biostudies-literature
| S-EPMC1223807 | biostudies-other
| S-EPMC3818338 | biostudies-literature
| S-EPMC5772368 | biostudies-literature