Ontology highlight
ABSTRACT:
SUBMITTER: Velikyan I
PROVIDER: S-EPMC6929622 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Velikyan Irina I Eriksson Olof O
Theranostics 20200101 1
In the light of theranostics/radiotheranostics and prospective of personalized medicine in diabetes and oncology, this review presents prior and current advances in the development of radiolabeled imaging and radiotherapeutic exendin-based agents targeting glucagon-like peptide-1 receptor. The review covers chemistry, preclinical, and clinical evaluation. Such critical aspects as structure-activity-relationship, stability, physiological potency, kidney uptake, and dosimetry are discussed. ...[more]