Ontology highlight
ABSTRACT:
SUBMITTER: Tasdogan A
PROVIDER: S-EPMC6930341 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Tasdogan Alpaslan A Faubert Brandon B Ramesh Vijayashree V Ubellacker Jessalyn M JM Shen Bo B Solmonson Ashley A Murphy Malea M MM Gu Zhimin Z Gu Wen W Martin Misty M Kasitinon Stacy Y SY Vandergriff Travis T Mathews Thomas P TP Zhao Zhiyu Z Schadendorf Dirk D DeBerardinis Ralph J RJ Morrison Sean J SJ
Nature 20191218 7788
Metastasis requires cancer cells to undergo metabolic changes that are poorly understood<sup>1-3</sup>. Here we show that metabolic differences among melanoma cells confer differences in metastatic potential as a result of differences in the function of the MCT1 transporter. In vivo isotope tracing analysis in patient-derived xenografts revealed differences in nutrient handling between efficiently and inefficiently metastasizing melanomas, with circulating lactate being a more prominent source o ...[more]