Ontology highlight
ABSTRACT:
SUBMITTER: Rivera-Avalos E
PROVIDER: S-EPMC6930466 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Rivera-Ávalos Ernesto E de Loera Denisse D Araujo-Huitrado Jorge Gustavo JG Escalante-García Ismailia Leilani IL Muñoz-Sánchez Miguel Antonio MA Hernández Hiram H López Jesús Adrián JA López Lluvia L
Molecules (Basel, Switzerland) 20191125 23
We performed an extensive analysis about the reaction conditions of the 1,4-Michael addition of amino acids to 1,4-naphthoquinone and substitution to 2,3-dichloronaphthoquinone, and a complete evaluation of stoichiometry, use of different bases, and the pH influence was performed. We were able to show that microwave-assisted synthesis is the best method for the synthesis of naphthoquinone-amino acid and chloride-naphthoquinone-amino acid derivatives with 79-91% and 78-91% yields, respectively. T ...[more]