Ontology highlight
ABSTRACT:
SUBMITTER: Simeon S
PROVIDER: S-EPMC6930640 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Simeon Saw S Jongkon Nathjanan N
Molecules (Basel, Switzerland) 20191201 23
Janus kinase 2 (JAK2) inhibitors represent a promising therapeutic class of anticancer agents against many myeloproliferative disorders. Bioactivity data on pIC 50 of 2229 JAK2 inhibitors were employed in the construction of quantitative structure-activity relationship (QSAR) models. The models were built from 100 data splits using decision tree (DT), support vector machine (SVM), deep neural network (DNN) and random forest (RF). The predictive power of RF models were assessed via 10-fold cross ...[more]