Ontology highlight
ABSTRACT:
SUBMITTER: Goulooze SC
PROVIDER: S-EPMC6930857 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Goulooze Sebastiaan C SC Ista Erwin E van Dijk Monique M Hankemeier Thomas T Tibboel Dick D Knibbe Catherijne A J CAJ Krekels Elke H J EHJ
CPT: pharmacometrics & systems pharmacology 20191015 12
Item-level data from composite scales can be analyzed with pharmacometric item response theory (IRT) models to improve the quantification of disease severity compared with the use of total composite scores. However, regular IRT models assume unidimensionality, which is violated in the scale measuring iatrogenic withdrawal in children because some items are also affected by pain, undersedation, or delirium. Here, we compare regular IRT modelling of pediatric iatrogenic withdrawal symptom data wit ...[more]