Copy Number Variation Pattern for Discriminating MACROD2 States of Colorectal Cancer Subtypes.
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ABSTRACT:
SUBMITTER: Zhang S
PROVIDER: S-EPMC6930883 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Copy Number Variation Pattern for Discriminating MACROD2 States of Colorectal Cancer Subtypes.
Zhang ShiQi S Pan XiaoYong X Zeng Tao T Guo Wei W Gan Zijun Z Zhang Yu-Hang YH Chen Lei L Zhang YunHua Y Huang Tao T Cai Yu-Dong YD
Frontiers in bioengineering and biotechnology 20191219
Copy number variation (CNV) is a common structural variation pattern of DNA, and it features a higher mutation rate than single-nucleotide polymorphisms (SNPs) and affects a larger fragment of genomes. CNV is related with the genesis of complex diseases and can thus be used as a strategy to identify novel cancer-predisposing markers or mechanisms. In particular, the frequent deletions of mono-ADP-ribosylhydrolase 2 (<i>MACROD2</i>) locus in human colorectal cancer (CRC) alters DNA repair and the ...[more]
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