Dataset Information

One-year changes in brain microstructure differentiate preclinical Huntington's disease stages.

ABSTRACT:

Objective

To determine whether brain imaging markers of tissue microstructure can detect the effect of disease progression across the preclinical stages of Huntington's disease.

Methods

Longitudinal microstructural changes in diffusion imaging metrics (mean diffusivity and fractional anisotropy) were investigated in participants with presymptomatic Huntington's disease (N = 35) stratified into three preclinical subgroups according to their estimated time until onset of symptoms, compared with age- and gender-matched healthy controls (N = 19) over a 1y period.

Results

Significant differences were found over the four groups in change of mean diffusivity in the posterior basal ganglia and the splenium of the corpus callosum. This overall effect was driven by significant differences between the group far-from-onset (FAR) of symptoms and the groups midway- (MID) and near-the-onset (NEAR) of symptoms. In particular, an initial decrease of mean diffusivity in the FAR group was followed by a subsequent increase in groups closer to onset of symptoms. The seemingly counter-intuitive decrease of mean diffusivity in the group furthest from onset of symptoms might be an early indicator of neuroinflammatory process preceding the neurodegenerative phase. In contrast, the only clinical measure that was able to capture a difference in 1y changes between the preclinical stages was the UHDRS confidence in motor score.

Conclusions

With sensitivity to longitudinal changes in brain microstructure within and between preclinical stages, and potential differential response to distinct pathophysiological mechanisms, diffusion imaging is a promising state marker for monitoring treatment response and identifying the optimal therapeutic window of opportunity in preclinical Huntington's disease.

SUBMITTER: Pflanz CP

PROVIDER: S-EPMC6931230 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Publications

One-year changes in brain microstructure differentiate preclinical Huntington's disease stages.

Pflanz Chris Patrick CP Charquero-Ballester Marina M Majid D S Adnan DSA Winkler Anderson M AM Vallée Emmanuel E Aron Adam R AR Jenkinson Mark M Douaud Gwenaëlle G

NeuroImage. Clinical 20191203

<h4>Objective</h4>To determine whether brain imaging markers of tissue microstructure can detect the effect of disease progression across the preclinical stages of Huntington's disease.<h4>Methods</h4>Longitudinal microstructural changes in diffusion imaging metrics (mean diffusivity and fractional anisotropy) were investigated in participants with presymptomatic Huntington's disease (N = 35) stratified into three preclinical subgroups according to their estimated time until onset of symptoms, c ...[more]

PMID: 31865023

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Dataset Information

One-year changes in brain microstructure differentiate preclinical Huntington's disease stages.

Objective

Methods

Results

Conclusions

Publications

One-year changes in brain microstructure differentiate preclinical Huntington's disease stages.

Similar Datasets

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