Ontology highlight
ABSTRACT:
SUBMITTER: Quan X
PROVIDER: S-EPMC6931887 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Quan Xingping X Du Hongzhi H Xu Jingjing J Hou Xiaoying X Gong Xiaofeng X Wu Yao Y Zhou Yuqi Y Jiang Jingwei J Lu Ligong L Yuan Shengtao S Yang Xiangyu X Shi Lei L Sun Li L
Frontiers in chemistry 20191219
Multidrug resistance is a serious problem and a common cause of cancer treatment failure, leading to patient death. Although numerous reversal resistance inhibitors have been evaluated in preclinical or clinical trials, efficient and low-toxicity reversal agents have not been identified. In this study, a series of novel quinoline compound derivatives from NSC23925 were designed to inhibit P-glycoprotein (P-gp). Among them, YS-7a showed a stronger inhibitory effect against P-gp than verapamil, as ...[more]